| Keegan-Michael Key | Jazzy James |
| Hugh Jackman | Janitor |
| Liam Neeson | Father Sean |
| Gal Gadot | Gal Gadot |
| Maya Rudolph | Julia |
| Fred Willard | Wally Kogen |
| Karen Gillan | Maisie |
| Don Cheadle | |
| Megan Mullally | Sarah Wiggum |
| Michael Sheen | William Masters |
| Colm Meaney | |
| Melissa McCarthy | Calvin |
| Peter Serafinowicz | Corporate CEO |
| John Legend | John Legend |
| Wallace Shawn | Wallace the Hernia |
| Ray Liotta | Morty Szyslak |
| Elliott Gould | |
| Andy García | Slick |
| Christopher Walken | |
| Bob Odenkirk | Mob lawyer |
| Matthew Perry | Ultrahouse 300 Matthew Perry Voice |
| Lisa Kudrow | Alex Whitney |
| Illeana Douglas | New age clerk |
| Stellan Skarsgård | Stellan Skarsgård |
| Bobby Moynihan | Tyler Boom |
| Ed Asner | |
| Debi Mazar | Minnie Szyslak |
| Natasha Rothwell | Bette |
| Olivia Colman | Lily |
| Russell Brand | |
| Victor Garber | Michael de Graaf |
| Kevin Nealon | |
| Fortune Feimster | Evelyn |
| Ricky Gervais | |
| Isabella Rossellini | Astrid Weller |
| Madelaine Petsch | Sloan |
| Nick Kroll | Lem |
| Lucy Liu | |
| Sarah Silverman | Rachel, Lisa's Imaginary Friend |
| Rhys Darby | |
| Henry Winkler | Ramrod |
| Will Forte | King Toot |
| Frank Welker | Santa's Little Helper / various animals |
| Marisa Tomei | Sara Sloane |
| Kiefer Sutherland | army colonel / Jack Bauer / Wayne Slater |
| Donald Sutherland | Hollis Hurlbut |
| Phil LaMarr | Hermes Conrad / Auctioneer / Male party guest |
| Grey DeLisle | Martin Prince / Young Woman |
| Sting | Sting |
| Mandy Patinkin | Hugh St. John Alastair Parkfield |
| Carmen Electra | |
| Snoop Dogg | Snoop Dogg |
| Nick Offerman | Captain Bowditch |
| Camila Mendes | Tessa Rose |
| Natasha Lyonne | Sophie |
| Lionel Richie | Lionel Richie |
| Michael Jackson | Leon Kompowsky |
| Tina Fey | |
| Christine Baranski | Christine Baranski |
| Hannibal Buress | Principal Finch |
| Treat Williams | Treat Williams |
| RZA | RZA |
| Liev Schreiber | |
| Helen Hunt | |
| Gillian Anderson | |
| Zooey Deschanel | Mary Spuckler |
| Alan Cumming | Loki |
| Dan Aykroyd | Postage Stamp Fellow |
| Bowen Yang | Richard |
| William H. Macy | William H. Macy |
| Parker Posey | |
| Patti LuPone | |
| Brooke Shields | Brooke Shields |
| Philip Rosenthal | Television father / Phil Rosenthal |
| Janeane Garofalo | Janeane Garofalo |
| George Harrison | George Harrison |
| Kimberly Brooks | Lewis Clark |
| Christopher Lloyd | |
| Bob Balaban | Narrador |
| Taika Waititi | Taika Waititi |
| Bob the Drag Queen | Bob the Drag Queen |
| Chris O'Dowd | Seamus (voice) |
| J.B. Smoove | |
| Andre Agassi | |
| Will Arnett | Deputy Director Gratman (voice) |
| Lizzy Caplan | Virginia Johnson (voice) |
| Fred Armisen | Terrence (voice) |
| Edi Patterson | Jessica (voice) |
| Jemaine Clement | Ethan Ballantyne (voice) |
| Utkarsh Ambudkar | Jay Nahasapeemapetilon (voice) |
| Jenny Slate | Piper Paisley (voice) |
| Matt Berry | Chester Arborday (voice) |
| Mark Hamill | Mark Hamill / Leavelle (voz) |
| Anna Faris | Female Hacker (voice) |
| Rachel Weisz | Dr. Thurston (voice) |
| Amy Poehler | Jenda (voice) |
| Eric Idle | Declan Desmond (voice) |
| Martin Short | Guthrie Frenel (voice) |
| Winona Ryder | Allison Taylor (voice) |
| Jack McBrayer | Ewell Freestone (voice) |
| Kirk Hammett | |
| Drew Barrymore | |
| Ray Romano | |
| Ringo Starr | Ringo Starr (voice) |
| Paul McCartney | Paul McCartney (voice) |
| Carice van Houten | |
| Kristen Schaal | Louise Belcher (voice) |
| Billy Eichner | Billy (voice) |
| Wanda Sykes | Therapist (voice) |
| Lily Tomlin | Tammy (voice) |
| Eddie Izzard | |
| Rich Sommer | |
| David Herman | Scruffy (voice) |
| Elisabeth Moss | |
| Edward James Olmos | Pit Master (voice) |
| Kaitlin Olson | Quinn Hopper (voice) |
| Cheech Marin | |
| Conan O'Brien | Conan O'Brien (voice) |
| David Hyde Pierce | Cecil Terwilliger (voice) |
| Cecily Strong | Megan Matheston (voice) |
| John Slattery | |
| Chris Martin | |
| Amber Riley | Aiesha (voice) |
| Zosia Mamet | Candace's Friend #2 (voice) |
| Glenn Close | Mona Simpson (voice) |
| Susan Sarandon | Susan Sarandon (voice) |
| Pharrell Williams | |
| Rashida Jones | |
| Stephen Fry | Terrance / Hazel / MI5 Man (voice) |
| Jeremy Irons | |
| Sidse Babett Knudsen | a Danish Woman (voice) |
| Paul Higgins | Hamish (voice) |
| Richard Gere | |
| Topher Grace | Donny (voice) |
| Greg Grunberg | Bad Robot Security Guard (voice) |
| Elizabeth Taylor | Maggie Simpson (voice) |
| Jane Lynch | Jeanie (voice) |
| Chris Redd | Trevor McBride (voice) |
| Billy West | Philip J. Fry / Dr. Zoidberg / Professor Farnsworth (voice) |
| Maurice LaMarche | Milo (voice) |
| Jess Harnell | Pancho (voice) |
| Anika Noni Rose | Rita LaFleur (voice) |
| Jason Alexander | Bourbon Verlander (voice) |
