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As Aventuras do Dr. Dolittle
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| Ator/Atriz | Personagem |
|---|---|
| Robert Downey Jr. | Dr. John Dolittle |
| Tom Holland | Jip |
| Emma Thompson | Poly |
| Craig Robinson | Kevin |
| Ralph Fiennes | Barry |
| John Cena | Yoshi |
| Kumail Nanjiani | Plimpton |
| Antonio Banderas | King Rassouli |
| Octavia Spencer | Dab-Dab (voz) |
| Jim Broadbent | Lorde Thomas Badgley |
| Jessie Buckley | Queen Victoria |
| Marion Cotillard | Tutu |
| Selena Gomez | Betsy (voz) |
| Jason Mantzoukas | James the Dragonfly (voz) |
| Michael Sheen | Dr. Blair Müdfly |
| Samson Kayo | Pirate |
| Frances de la Tour | Dragon (voice) |
| Scott Menville | Army Ant (voice) |
| Nick Fisher | Mini the Sugar Glider (voice) |
| Ralph Ineson | Arnall Stubbins |
| Rami Malek | Chee-Chee (voice) |
| Oliver Chris | Sir Gareth |
| Will Arnett | Rabbit (voice) (uncredited) |
| Stewart Scudamore | Pirate |
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